For Animal Use Only
NESADE
Solution for Injection
Veterinary Vitamin
COMPOSITION
NES-AD3E Solution for Injection is a clear yellow colored sterile solution; each 1 ml contains 105.000 IU Vitamin A (Palmitate), 52.500 IU Vitamin Dз (Cholecalciferol) and 50 mg Vitamin E (Acetate); contains 18 mg of benzyl alcohol as a preservative and 5 mg of butylhydroxytoluene as an antioxidant.
PHARMACOLOGICAL PROPERTIES
NES-AD3E Solution for Injection is a formulation containing vitamins A, Dз, and E. It shows high bioavailability by being absorbed for a long time after intramuscular injection. It reaches its highest level in the blood in a short time. It also maintains its protective and therapeutic effect by being stored in the liver.
Vitamin A: Provides regeneration and normal function of epithelial tissue, increases body resistance against infectious diseases and ensures growth. It supports protein, carbohydrate, and fat metabolism. It prevents night blindness. In its deficiency, the integrity of epithelial tissues is disrupted, and hyperkeratosis-type discomfort occurs. When administered orally, it is absorbed by diffusion from the epithelial cells of the small intestine and reaches its peak concentration in plasma after about 4 hours. Its amount in plasma decreases to the extent that it is stored in the liver. Absorption continues in the intestines until the concentration in the liver reaches the peak (2 mg./kg./c.a.). The unabsorbed part is excreted with the stool.
Vitamin Dз: It regulates the metabolism of calcium and phosphorus and increases their biological use. The development and hardening of the skeletal tissue, ensures the formation and consolidation of the eggshell in poultry. In case of deficiency, calcium-phosphorus metabolism is disturbed. Bone and skeletal disorders such as rickets and osteomalacia occur. When administered orally, it is completely absorbed from the gastrointestinal tract. Absorbed Vitamin D3 first enters the lymph circulation and, by binding to the lipoprotein, passes into the blood circulation. The plasma half-life is approximately 20-25 hours. It is stored in all tissues, especially in adipose tissue.
Vitamin E: Vitamin E ensures the development and normal function of the genital organs. It facilitates fertilization and pregnancy. It regulates the metabolism of carbohydrates and creatinine. It supports development and growth. Increases hatching ability. It plays a role in neutralizing free-flowing oxygen groups with its antioxidant feature. It prevents the oxidation of fatty acids, which are the building blocks of cell membranes containing more than one oil in their structure, and prolongs their biological half-life. At the same time, thanks to its antioxidant action mechanism, it also ensures that the cell membrane is durable. Vitamin E, after application, first enters the blood circulation and is then stored in all body tissues.
AREA OF USE / INDICATIONS
NES-AD3E Solution for Injection is used to eliminate the deficiencies of vitamins A, Dз, and E in cattle, sheep, goats, and horses, and in the treatment of diseases related to the deficiencies of these vitamins, to meet the increased vitamin needs in the treatment of rickets in young animals, bone diseases and osteomalacia in adults due to vitamin D deficiency.
USAGE AND DOSAGE
Pharmacological dose of NES-AD3E Solution for Injection
Vitamin A: 2.625 IU/kg body weight,
Vitamin D3: 1,310 IU/kg body weight
Vitamin E: 1.25 mg/kg body weight.
Unless recommended otherwise by the veterinarian, NES-AD3E Solution for Injection is administered intramuscularly and subcutaneously according to the dosage table below;
| Animal Type | NES-AD3E Solution for Injection | Route of administration |
| Cattle | 5 – 10 ml | Deep intramuscular |
| Horse | 5 – 10 ml | Deep intramuscular |
| Calf, Heifer | 2.5 – 5 ml | Deep intramuscular |
| Calf, Foal | 2 – 3 ml | Deep intramuscular |
| Sheep, Goat | 1 -2 ml | Subcutaneous |
| Lamb, Kid | 0.5 – 1 ml | Subcutaneous |
For the prevention of vitamin deficiency, the application can be repeated every 2-3 months. In the treatment of vitamin deficiency, the duration can be further shortened. The time intervals for application can be changed depending on the december type, maintenance-nutritional conditions, and the degree of deficiency.
SPECIFIC CLINICAL INFORMATION AND WARNINGS FOR TARGET SPECIES
Drug applications for multi-directional efficiency-enhancing, protective and therapeutic purposes can be repeated once a month depending on the dose. In breeding animals, drug applications are prescribed 7-8 weeks before the breeding season. When applied in the last 1/3 of pregnancy, it supports the healthy development of the offspring.
UNDESIRED EFFECTS
A small swelling may occur at the injection site, which disappears on its own after a short time.
DRUG INTERACTIONS
Since there is no information on the incompatibility of Vitamin A (Palmitate), Vitamin Dз, and Vitamin E (Acetate) with other drugs, it should not be used with other veterinary products.
SYMPTOMS OF OVERDOSE, PRECAUTIONS, AND ANTIDOTE
High doses and long-term administration of vitamin D can lead to the release of calcium and phosphorus from the bones, thereby increasing the level of these ions in the bloodstream. As a result, calcification may occur in some soft tissues and organs. Excessive use of vitamin A can cause hypervitaminosis. Intervention with antihistamine, corticosteroid or atropine.
RESIDUAL WARNINGS FOR FOOD PRODUCING ANIMALS
Drug Residue Elimination Period: It is “0” days for meat and milk.
CONTRAINDICATIONS
NES-AD3E Solution for Injection has no contraindications when used as recommended.
GENERAL PRECAUTIONS
Read the leaflet before use. Keep out of reach of children. Consult your veterinarian in case of unexpected effect and before use.
NES-AD3E Solution for Injection contains benzyl alcohol as an antimicrobial. During the application, the rules of asepsis and antisepsis should be followed. A sterile syringe should be used. It is recommended not to puncture the stopper more than 20 times after the first use. Avoid direct contact with the product. If you accidentally inject yourself, seek medical treatment immediately and show the product leaflet to your doctor. Pregnant women should not apply this product because of the vitamin A content and the risk of self-injection.
STORAGE CONDITIONS AND SHELF LIFE
Store at room temperature (15˚C-25˚C) in its own package. Protect from direct sunlight, do not refrigerate or freeze. Shelf life is 2 years from the date of manufacture. From the first use, it should be consumed within 28 days, provided that the rules of asepsis-antisepsis are followed and stored as indicated.
TRADE DRESS
NES-AD3E Solution for Injection is enclosed in a cardboard box with a 20 mm gray bromobutyl rubber stopper and a 20 mm transparent printed flip-off cap in 50 ml and 100 ml amber colored type II glass vials, and a 32 mm gray bromobutyl rubber stopper in 250 ml amber colored type II glass vials. It is offered for sale by plastering with a 32 mm transparent printed flip-off cover.
PLACE AND CONDITIONS OF SALE
Sold in veterinary offices and pharmacies with a veterinarian’s prescription.
